Cefuroxime is a second generation cephalosporin antibacterial used in the treatment of susceptible infections. These have included bone and joint infections, bronchitis (and other lower respiratory-tract infections), gonorrhoea, meningitis (although treatment failures have been reported in H. influenzae meningitis), otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft-tissue infections), and urinary tract infections. It is also used for surgical infection prophylaxis.
Each film-coated tablet contains Cefuroxime (as Axetil) 500 mg.
Alu-alu blister pack of 4’s (Box of 24’s)
Indications & Dosage
See insert for complete information
Dosage and Administration
Usual oral doses are 125mg twice daily for uncomplicated urinary-tract infections and 250 to 500mg twice daily for respiratory tract infections. A suggested dose for children more than 3 months of age is 125mg twice daily or 10mg per kg body-weight twice daily to a maximum of 250mg daily. Children over 2 years of age with otitis media may be given 250mg twice daily or 15mg per kg twice daily to a maximum of 500mg daily.
By injection the usual dose is 750mg of Cefuroxime every 8 hours but in more severe infections 1.5g may be given intravenously every 8 or 6 hours. Infants and children can be given 30 to 60mg per kg body-weight daily, increased to I00 mg per kg daily if necessary, given in 3 or 4 divided doses. Neonates may be given similar total daily doses but administered in 2 or 3 divided doses.
Parenteral doses may need to be reduced in renal impairment. The manufacturers suggests that the usual adult dose of 750mg should only be given twice daily when the creatinine clearance is between 10 and 20 mL per minute and once daily when it is below 10 mL per minute. Patients undergoing haemodialysis should receive an additional 750mg dose following each dialysis; those undergoing continuous peritoneal dialysis may be given 750mg twice daily.
For the treatment of meningitis due to sensitive strains of bacteria, Cefuroxime is administered intravenously in doses of 3g every 8 hours. Infants and children are given 200 to 240mg per kg daily intravenously in 3 or 4 divided doses which may be decreased to 10Omg per kg daily after 3 days or when there is clinical improvement. For neonates, a dose of 100mg per kg daily, decreased to 50mg per kg daily when indicated and has been recommended.
In the treatment of gonorrhoea a single dose of 1.5g by intramuscular injection, divided between 2 injection sites has been suggested. A single Ig oral dose of Cefuroxime has been given for uncompli- cated gonorrhoea. In each case an oral dose of probenecid Ig may be administered in conjunction with Cefuroxime.
For surgical infection prophylaxis the usual dose is 1.5g of Cefuroxime intravenously prior to the procedure; this may be supplemented by 750mg intravenously or intramuscularly every 8 hours for up to 24 to 48 hours depending upon the procedure.
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