Indications & Dosage

Indications:

Used in the management of all conditions in which corticosteroids are indicated. When oral therapy is not feasible, and the strength, dosage form and route of administration of the drug reasonably lend the preparation to the treatment of the condition. Also for replacement therapy in acute or chronic adrenocortical insufficiency.

See insert for complete information

Dosage and Administration

The usual dose is the equivalent of 100 to 500 mg of hydrocortisone. This dose may be repeated at intervals of 2, 4, 6 hours according to the severity of the condition and the patient’s response. In pediatric patients, the initial dose of hydrocortisone may vary depending on the specific disease entity being treated. The range of initial doses is 0.56 to 8mg/kg/day in three or four divided doses (20 to 240mg/m2bsa/day). In the treatment of severe shock the equivalent of up to 50 mg per kg body-weight in 24 hours has been given by slow intravenous injection over several minutes in divided doses, or by intravenous infusion. Fluids and Electrolytes should be given as necessary to correct any associated metabolic disorder. Similar doses to those specified above may also be given intramuscularly but the response is likely to be less rapid than that observed following intravenous administration. Hydrocortisone Sodium Succinate may be given by intravenous injection in a dose equivalent to 100mg to 300mg of Hydrocortisone.