Indications & Dosage

Indications:

For treatment of bacterial infections caused by susceptible microorganism i.e.
1. As an adjunctive treatment of chronic bone and joint infections, and acute hematogenous osteomyelitis caused by staphylococci.
2. Female pelvic infections, including endometritis, non-gonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infections caused by susceptible anaerobes.
3. Intra-abdominal infections such as peritonitis and abscesses caused by susceptible anaerobes.
4. Pneumonia including serious respiratory tract infections (such as empyema, pneumonitis, and lung abscesses) caused by susceptible anaerobes.
5. Septicemia caused by streptococci and staphylococci.
6. Skin and soft tissue infections caused by susceptible anaerobes, streptococci, and staphylococci.

Dosage and Administration

Usual adult and adolescent dose:
Intramuscular or intravenous
– Serious infections: 600-1200 mg/day in 2,3 or 4 equal doses
– More severe infections: 1200-1700 mg/day in 2,3 or 4 equal doses
– For more serious infections, these doses may have to be increased. In life-threatening situations due to
either aerobes or anaerobes these doses may be increased. Doses of as much as 4800 mg daily have been
given intravenously to adults.
(Single intramuscular injections of greater than 600 mg are not recommended and dosage should not exceed 2.7
gm daily)

Usual pediatric dose:
Intramuscular or intravenous
– 20 to 40 mg/kg/day in 3 or 4 equal doses. The higher doses would be used for more severe infections. As an
alternative to dosing on body weight basis, pediatric patients may be dosed on the basis of square meters body
surface: 350mg/m2/day for serious infections and 450 mg/m2/day for more severe infections.

See insert for complete information