Cefuroxime (750 mg) – Powder for Injection (I.M./I.V.)


Cefuroxime (750 mg) – Powder for Injection (I.M./I.V.)

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    Cefuroxime Sodium is almost white or yellowish powder for injection.


    Each vial contains 750mg Cefuroxime (as sodium).


    Cefuroxime 750mg powder for injection (Box of 1’s)

    Indications & Dosage


    Cefuroxime sodium is a broad-spectrum, cephalosporin antibiotic used in the treatment of susceptible infections. These have included bone and joint infections, bronchitis and other lower respiratory tract infections, gonorrhea, meningitis – although treatment failures have been reported in H. influenzae meningitis, otitis media, peritonitis, (prophylaxis), and urinary tract infections. The preoperative prophylactic administration of infection surgical infections, soft-tissue including infections skin sinusitis, pharyngitis, Cefuroxime may prevent the growth of susceptible disease causing bacteria and thereby may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures that are classified as clean-contaminated or potentially contaminated procedures. Cefuroxime has also been effective during open heart surgery for surgical patients in whom infections at the operative site would present a serious risk. For these patients it is recommended that therapy with Cefuroxime be continued for at least 48 hours after the surgical procedure ends. If an infection is present, specimens for culture should be obtained for the identification of the causative organism, and appropriate antimicrobial therapy should be instituted.

    Dosage and Administration

    Cefuroxime sodium may be given by IM or deep slow IV injection over 3 – 5 minutes, or by IV infusion.

    Adult: The usual dose is 750mg every 8 hours but in more severe infections 1.5g may be given intravenously every 8 to 6 hours. Parenteral doses may need to be reduced in renal failure. The suggested usual adult dose of 750mg should only be given twice daily when the creatinine clearance is between 10 and 20mL per minute and once daily when it is below 10mL per minute. Patients undergoing haemodialysis should receive additional 750mg dose following each dialysis.

    Infants and Children: Doses can be given 30 to 60mg per kg body-weight daily increased to 100mg per kg daily if necessary, given in 3 or 4 divided doses.

    Neonates: Doses can be given 30 to 60mg per kg body weight, increased to 100mg per kg daily in 2 or 3 divided doses. For the treatment of meningitis due to sensitive strains of bacteria, cefuroxime is administered intravenously in doses of 3g every 8 hours. Infants and children are given 200 to 240mg per kg daily intravenously in 3 or 4 divided doses, which may be decreased to 100mg per kg daily after 3 days or when there is clinical improvement.
    For neonates, a dose of 100mg per kg daily, decreased to 50mg per kg daily when indicated, has been recommended. In the treatment of gonorrhoea a single dose of 1.5g by intramuscular injection, divided between 2 injection sites, has been suggested. A single 1g oral dose of cefuroxime has been given for uncomplicated gonorrhea. In each case an oral dose of probenecid 1g may be administered in conjunction with cefuroxime. For surgical infection prophylaxis the usual dose is 1.5g of cefuroxime intravenously prior to the procedure followed by 750mg intravenously or intramuscularly every 8 hours for up to 24 to 48 hours. For total joint replacement 1.5g of cefuroxime powder may be mixed with the methylmethacrylate cement. OR AS PRESCRIBED BY THE PHYSICIAN


    Imported and Distributed by:
    8F RBMT Bldg., corner C3 and 5th Ave.,
    East Grace Park, Caloocan City

    Manufactured by:
    Henan, China


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