Hyoscine-N- Butylbromide (Buscogen) Solution for Injection is a clear colorless solution.
Each mL contains:
Hyoscine-N-Butylbromide … 20mg
1mL USP Type – 1 clear colorless glass ampule in plastic tray (box of 10’s)
Indications & Dosage
Hyoscine is a tertiary amine antimuscarinic with central and peripheral actions. It is a more powerful suppressant of salivation than atropine, and usually slows rather than increases heart rate, especially in low doses. Its central action differs from that of atropine in that it depresses the cerebral cortex and produces drowsiness and amnesia. Hyoscine hydrobromide is also a tertiary amine, whereas hyoscine butylbromide, hyoscine methobromide, and hyoscine methonitrate are quaternary ammonium derivatives.
Hyoscine and hyoscine hydrobromide are used in the management of motion sickness and other forms of nausea and vomiting ; hyoscine hydrobromide is also given as a premedicant in anaesthesia , and to produce mydriasis and cycloplegia. Hyoscine butylbromide and other quaternary ammonium derivatives are used in conditions associated with visceral spasms. In addition, hyoscine methobromide has been employed as an adjunct in the treatment of peptic ulcer disease.
Other hyoscine salts or derivatives that have been used include hyoscine borate, hyoscine hydrochloride, and hyoscine oxide hydrobromide.
Dosage and Administration
Administer by intramuscular or intravenous injection.
Adults : 20mg
Children under 15 years : 5mg
Administered can be repeated after 30 minutes when necessary. Hyoscine-N-Butylbromide injection may be diluted
with Dextrose 5 % or with Sodium Chloride 0.9 % Solution for Infusion.
Use only once or discard any remaining portion.
For single use or single dose only.
See insert for complete information
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