Indications & Dosage

Indications:

Ampicillin and Sulbactam for Injection is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below:
– Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli,*
Klebsiella spp.* (including K. pneumoniae*), Proteus mirabilis,* Bacteroides fragilis,* Enterobacter spp.,* and Acinetobacter
calcoaceticus.*
– Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella spp. (including K.
pneumoniae*), Bacteroides spp. (including B. fragilis), and Enterobacter spp.*
– Gynecological Infections caused by beta-lactamase producing strains of Escherichia coli, * and Bacteroides spp.* (including B.
fragilis*). * Efficacy for this organism in this organ system was studied in fewer than 10 infections.

Dosage and Administration

The recommended adult dosage of this product is 1.5 g (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt) to 3 g
(2 g ampicillin as the sodium salt plus 1 g sulbactam as the sodium salt) every six hours. This 1.5 to 3 g range represents the total of ampicillin content plus the sulbactam content, and corresponds to a range of 1 g ampicillin/0.5 g sulbactam to 2 g ampicillin/1 g sulbactam. The total dose of sulbactam should not exceed 4 grams per day.